William J. Rowe
Medical U. Ohio at Toledo, Keswick, VA 22947, USA
Neil Armstrong syndrome triggered by very common earth related magnesium (Mg) deficits, invariably with spaces flight (SF); invariable dehydration with exercise-induced sweating, Mg loss and through kidneys; plasma leaks through oxidative stress-induced defective capillaries; loss of thirst mechanism; in turn, angiotensin, catecholamine (C) elevations to twice earth levels when supine; vicious cycles with Mg ion deficits; can trigger C cardiomyopathy i.e. acute temporary heart failure. Normal earth CO2 levels about 0.03% ; with SF, levels can be 0.5-.7% (on Mir;) this, postulated to trigger calcium (Ca) overload with in turn coronary vasospasm, injuries to mitochondria along with impairment in telomere function; its synthesis, dependent upon Mg and with impaired telomere function, decreased cardiac function; telomerase is Mg-dependent. Since Mg required for thermoregulation, intensified by SF-exercise for at least 2 hours exercise/day; invariable SF malabsorption with Mg levels reduced to p<0.0001 even though serum Mg lacks sensitivity. Neil Armstrong informed Houston twice at 4 minute interval, of shortness of breath with heart rate up to 160 (tachycardia conducive to oxidative stress) with marked reduction to 60, half hour before pacific-splashdown over three days later; severe thirst, quenched with in turn, reduced postulated high C. Mg, powerful antioxidant, Ca blocker. Syndrome: Severe dyspnea, thirst, tachycardia; the latter, corrected by water replenishment; one of only 4 published SF syndromes; applicable to Earth in post-menopausal women, particularly if taking Ca supplements which reduce Mg absorption; marathoners at finish line; in tropics with water shortages; may be corrected quickly with I.V fluids or subcutaneous Mg.
Keywords: Syndrome, catecholamines, magnesium, dehydration, telomeres.