SINGLE STEP SYNTHESIS OF CURCUMIN LOADED ZEOLITIC IMIDAZOLATE FRAMEWORKS: PH STIMULI RELEASE FOR C

Jaspreet Kaur Randhawa and Ashish Tiwari

School of Engineering, Indain Institute of Technology, Mandi (IITMandi) India

Abstract

Metal organic frameworks (MOFs) generally known as porous crystalline materials are very promising in various applications such as catalysis, energy storage and biomedical. The tunable porous microstructure and functional surface properties make them superior material compare to their analogous such as, zeolites, porous inorganic materials and mesoporous materials. MOFs have shown advantageous application as a carrier molecule as they enable host-guest interaction with foreign species by different interaction forces. Nanosized metal organic frameworks show great utility in biomedical application especially in drug delivery. Thus, hydrophobic drugs can be successfully delivered avoiding nay premature loss with maximum bioavailability. Curcumin loaded zeolitic imidazolate frameworks (CCM-ZIF-8) were fabricated in single step facile synthesis method in present work. The as-synthesized CCM-ZIF-8 showed ultra high drug loading efficiency of 83.33%, particle size below 100 nm, smooth morphology, positive surface zeta potential, high surface area and large pore volume and high thermal stability upto 450°C. The spectroscopic analysis successfully confirmed curcumin encapsulation inside the ZIF-8 frameworks. The external stimuli responsive drug release experiments were performed with change in pH and biomimetic cell membrane like environment of Micelles and Liposomes. The in vitro drug release results demonstrated pH responsive CCM release from CCM-ZIF-8 in acidic conditions. The CCM release rate was higher in acidic medium than physiological. The work enlightens single step approach of CCM-ZIF-8 synthesis and synthesized CCM-ZIF-8 could be used for stimuli responsive drug delivery in cancer therapy in near future of biomedicine

Keywords: Metal organic frame works cancer, target drug therapy.