Abstracts

PLENARY SPEAKERS

Ferid Murad
(Nobel Laureate)
The Stanford VA Hospital, Palo Alto, CA,
USA
APPLICATION OF NITRIC OXIDE RESEARCH TO DRUG DEVELOPMENT
Stuart Schreiber
Howard Hughes Medical Institute, Harvard University and Broad Institute, Cambridge, MA,
USA
CHEMISTRY TOWARDS NOVEL MECHANISM-OF-ACTION COMPOUNDS IN THERAPEUTICS DISCOVERY
Alexander D MacKerell, Jr.
University of Maryland Computer-Aided Drug Design Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
CAN CADD DRIVE DRUG DESIGN AND DEVELOPMENT? RAPID ESTIMATION OF RELATIVE BINDING AFFINITIES BASED ON PRE-COMPUTED ENSEMBLES
Shuji Ogino
Chief, Division of MPE Molecular Pathological Epidemiology, Brigham and Women’s Hospital
Professor of Pathology and Epidemiology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, and Harvard T.H. Chan School of Public Health , Boston, MA,
USA
EMERGING PHARMACO-MPE (MOLECULAR PATHOLOGICAL EPIDEMIOLOGY) AND IMMUNO-MPE FOR PRECISION MEDICINE
Rudolf Jaenisch
Whitehead Institute for Biomedical Research and Department of Biology, MIT, Cambridge, MA 02124,
USA
EPIGENETICS, STEM CELLS AND DISEASE RESEARCH
Steven A. Carr
Institute of MIT and Harvard, Boston, MA,
USA
QUANTITATIVE PROTEOMICS IN BIOLOGY, CHEMISTRY AND MEDICINE
Vladimir Torchilin
University Distinguished Professor Director, Center for Pharmaceutical Biotechnology and Nanomedicine Northeastern University Boston, MA
United States
STIMULI-SENSITIVE MULTIFUNCTIONAL COMBINATION NANOPREPARATIONS OF siRNA AND CHEMOTHERAPEUTIC DRUGS TO TREAT MULTIDRUG RESISTANT CANCER
Kenneth C. Anderson
Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215,
USA
TARGETTING ACHILLES HEELS IN MYELOMA
Stephen J. Elledge
Department of Genetics Harvard Medical School MA
United States
ANEUPLOIDY PROMOTES CELL PROLIFERATION AND INHIBITS IMMUNE SURVEILLANCE
D.K. Lahiri
Department of Psychiatry and of Medical & Molecular Genetics, IADC, Indiana University School of Medicine, Indianapolis, IN,
USA
ROLE OF NON-CODING RNAS IN ALZHEIMER'S DISEASE

KEYNOTE SPEAKERS

Ali Khademhosseini
Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA
USA
Nano- and Microfabricated Hydrogels for Regenerative Engineering
Simon C. Robson
Beth Israel Deaconess Medical Center, Division of Gastroenterology and Hepatology, Harvard Medical School, Boston, MA 02215,
USA
THE ECTONUCLEOTIDASE CD39 IS A CHECKPOINT INHIBITOR TARGET IN CANCER
S. Samar Hasnain
Barkla X-ray Laboratory of Biophysics, Institute of Integrative Biology, University of Liverpool, Liverpool,
UK
STRUCTURE BASED APPROACH IN DRUG DISCOVERY AND IDENTIFICATION OF LIGAND BINDING SITES
M. Iqbal Choudhary
International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi, Karachi-75270,
Pakistan
NEW PHARMACOPHORES FROM MEDICINAL PLANTS
Thomas Jay Webster
Department of Chemical Engineering, Northeastern University, Boston, MA,
USA
THE AGE OF “NANO-BIOTICS”: SELF-ASSEMBLED MATERIALS AS NOVEL ANTIBACTER-IAL AGENTS AGAINST DRUG-RESISTANCE BACTERIA
Rakesh Kumar
Cancer Biology Program, Rajiv Gandhi Center of Biotechnology, Thiruvananthapuram 695014,
India
ERBB2 TRANSCRIPTOME: FROM BIOLOGY TO GENOMICS TO BIOLOGY
Academic CRO/Industrial Collaborations in Drug Discovery (Track)
POSTER PRESENTER
Adijat Funke Ogundola
Department of Botany, University of Fort Hare, Alice, Eastern Cape,
South Africa
THE EFFECT OF SOIL TYPES ON CHEMICAL COMPOSITIONS AND ANTIOXIDANT PROPERTIES OF SOLANUM NIGRUM (L.)
Anti Infectives (Track)
SESSION SPEAKER
Concepción González-Bello
Dept. of Organic Chemistry, Universidade de Santiago de Compostela, CIQUS, Spain
Spain
FREEZING THE ESSENTIAL MOTION OF KEY BACTERIAL ENZYMES – A STRATEGY FOR ANTIBIOTIC DRUG DISCOVERY
Mario Milani
Biophysics Institute, National Research Council (CNR),
Italy
THE DIFFICULT PATH TOWARD THE KNOWLEDGE: AN ONGOING STORY ON NEW DENGUE VIRUS INHIBITORS
Yanxiang Zhao
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University,
Hong Kong
MOLECULAR MECHANISM OF β-LACTAMASES AND IMPLICATION FOR ANTIBIOTIC RESISTANCE
POSTER PRESENTER
Mahmood Ahmed
Department of Chemistry, University of the Punjab, Lahore,
Pakistan
AZOMETHINES, ISOXAZOLE, N-SUBSTITUTED PYRAZOLES AND PYRIMIDINE RING CONTAINING CURCUMIN DERIVATIVES
Jennifer Hsuan-Yu Lin
Faculty of Pharmacy, University of Sydney, Sydney,
Australia
FTSZ DIVISIONAL PROTEIN AS THERAPEUTIC TARGET FOR NOVEL ANTIBACTERIAL AGENTS
Bioactive Lipids (Track)
POSTER PRESENTER
Zanginyan H.
Molecular membranology, Institute of Molecular Biology NAS RA, Yerevan,
Armenia
VIOLATION OF TISSUE METABOLISM OF PHOSPHOLIPIDS WITH HYDATID DISEASE
Biologics (Track)
SESSION SPEAKER
Muhammad Younus
Department of Pathobiology, Pakistan College of Veterinary and Animal Sciences, Jhang,
Pakistan
LEAD RESIDUES IN LOHI SHEEP: A HEMATO-BIOCHEMICAL AND HISTOPATHOLOGICAL STUDY
Cardiovascular Drug Discovery & Therapy (Track)
POSTER PRESENTER
Hamada Mansour Abdelaal Abdelaziz
Faculty of Pharmacy, Al-Zaytooanh University of Jordan, Amman,
Jordan
CETP INHIBITORY ACTIVITY OF CHLOROBENZYL BENZAMIDES: QPLD DOCKING, PHARMACOPHORE MAPPING, AND SYNTHESIS
Cancer Biomarkers (Track)
SESSION SPEAKER
Daniela Dinulescu
Department of Pathology, Harvard Medical School,
USA
PREDICTIVE AND PROGNOSTIC BIOMARKERS FOR CHEMORESISTANCE IN OVARIAN CANCER
Sunita R. Setlur
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115,
USA
EARLY microRNA BIOMARKERS OF HIGH GRADE SEROUS OVARIAN CANCER
Hong Zhang
Department of Neurobiology, School of Basic Medical Sciences, Beijing Institute for Brain Disorders and Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, Capital Medical University, Beijing 100069,
China
METABOTROPIC GLUTAMATE RECEPTOR 5 MEDIATES THE SUPPRESSIVE EFFECT OF 6-OHDA-INDUCED MODEL OF PARKINSON'S DISEASE ON LIVER CANCER
Cancer Targeted Drug Delivery (Track)
SESSION SPEAKER
Amr Amin
Biology Department, UAE University,
UAE
DEVELOPMENT OF A THERAPEUTIC MODEL OF PRECANCEROUS LIVER USING CROCIN-COATED MAGNETITE NANOPARTICLES
POSTER PRESENTER
Vinaya Kambappa
Department of Oncologic Sciences, Mitchell Cancer Institute, Alabama 36604,
USA
SYNTHESIS AND IN VITRO EVALUATION OF NOVEL QUINOZOLINE DERIVATIVES AS POTENT EGFR INHIBITORS IN LUNG
Chemistry (Track)
SESSION SPEAKER
S. B. Quraishi
Chemistry Division, Atomic Energy Centre, Dhaka,
Bangladesh
A NEW APPROACH FOR DIAGNOSIS OF WILSON’S DISEASE AND BANGLADESH PERSPECTIVE
Maria Grishina
Laboratory of Computational Modelling of Drugs South Ural State University, Chelyabinsk,
Russia
WWW.CHEMOSOPHIA.COM ON-LINE COMPUTATIONAL SERVICES FOR IN SILICO DRUG DESIGN AND SCREENING
POSTER PRESENTER
Dillip K. Mohanty
Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant,
USA
DICHOTOMOUS NITRIC OXIDE RELEASE PROFILES OF TWO ISOMERIC FAMILIES OF N-NITROSATED SECONDARY AMINES
Mohammad A. Khasawneh
Department of Chemistry, United Arab Emirates University, Al Ain,
United Arab Emirates
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF POTENT 1-(2,5-DIMETHOXY-BENZYL)-4-ARYLPIPERAZINES
CNS Drug Discovery & Therapy (Track)
TRACK CHAIRS
Ricardo Garay
Inserm Hôpital Marie-Lannelongue Université Paris-Sud, 92350 Le-Plessis-Robinson
France
Title Awaited
Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine Neuroscience Research Center Indianapolis, IN 46202
USA
Title Awaited
INVITED SPEAKERS
Nigel H. Greig
Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224,
USA
PROINFLAMMATORY CYTOKINE INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
Jack T. Rogers
Department of Psychiatry-Neuroscience and Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA and Department of Neurology, Brigham and Women’s Hospital, Cambridge, MA,
USA
COOPERATIVE RNA MODULATION TO IMPROVE IRON HOMEOSTASIS SPECIFIC TO NEURONS WHILE PROVIDING ANTI-AMYLOID EFFICACY AS A POTENTIAL ALZHEIMER’S DISEASE THERAPY
Cynthia A. Lemere
Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA,
USA
TARGETING A PATHOGENIC SEED, PYROGLU3 AΒ, IN ALZHEIMER’S DISEASE
Kumar Sambamurti
Medical University of South Carolina, Charleston, SC, USA
A COMPLEX CASCADE OF PRODUCTION AND DEGRADATION DETERMINES THE YIELD OF AΒ YIELD IN VIVO
Riqiang Yan
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 USA
INHIBITION OF BACE1 FOR ALZHEIMER’S THERAPY: LESSONS FROM CONDITIONAL DELETION OF BACE1 IN AD MOUSE MODELS
SESSION SPEAKER
Horng-Jyh Harn
Bioinovation center, Buddhist Tzu Chi Medical Foundation, Room 615, 6F, Xie-Li building, No. 707, Sec. 3, Chung Yang Rd., Hualien 970, Taiwan,
Republic of China
TARGETING THERAPY OF MALIGNANT BRAIN TUMOR BY A LOCAL INTERSTITIAL DELIVERY SYSTEM LOADING WITH A NOVEL SMALL MOLECULE IND FOR PHASE I/IIA APPROVED BY FDA (IND 128388)
Benjamin Wolozin
Dept. of Pharmacology and Neurology, Boston University Medical Campus, Boston, MA,
USA
STRESS GRANULES AND NEURODEGENERATION: NOVEL TARGETS FOR THERAPY IN AMYOTROPHIC LATERAL SCLEROSIS AND ALZHEIMER’S DISEASE
Nicolas Marie
Neuroplasticité et thérapies des addictions » / Inserm UMR‐S 1124 /, Université Paris Descartes, 75006 Paris
France
THE MGLU7 RECEPTOR: A NEW TARGET IN THE THERAPY OF OPIATES ADDICTION?
William Andrew Kofke
Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA
FUNCTIONAL GENOMICS IN HUMAN BRAIN ISCHEMIA
Colin K. Combs
Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND 58202-9037, USA
STRATEGIES FOR INHIBITING THE Aβ-STIMULATED MICROGLIAL SIGNALING RESPONSE IN ALZHEIMER’S DISEASE
Debjani Roy
Department of Biophysics, Bose Institute, Acharya J.C. Bose Centenary Building, Kolkata, India
EPIGENETICS IN ALZHEIMER’S DISEASE: THE COMPUTATIONAL SYSTEMS BIOLOGY PARADIGM FOR UNDERSTANDING THE EPIGENETIC-BASED MARKERS AND DRUGS
Xudong Huang
Neurochemistry Laboratory, Departments of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129,
USA
MACHINE LEARNING-BASED CLASSIFICATION OF FDG-PET IMAGES FROM ADNI DATABASE
POSTER PRESENTER
Gemma Eftimiadi
Study Group of the Movement Disorders and Behavioral Child, GNOSIS Non Profit Research Organization, Carrù CN,
Italy
STAPHYLOCOCCAL PROTEIN A AS A PHARMACOLOGICAL TREATMENT FOR AUTOIMMUNE MOVEMENT DISORDERS
Kuo-Wei Hsueh
Bioinnovation Center, Tzu Chu Fundation, Hualien,
Taiwan
HK-001 ATTENUATE AMYOTROPHIC LATERAL SCLEROSIS SYMPTOMS THROUGH DOWN-REGULATION AUTOPHAGY
José Peea-Sasiaín
UNISALUD - Universidad Nacional de Colombia, Bogota,
Colombia
MORPHINE, AND SOME OF ITS ENDOGENOUS SYNTHESIS PRECURSORS IN ANIMALS, FOR PARKINSON´S DISEASE TREATMENT
H.M. Mazhar Asjad
Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Waehringerstrasse 13A, 1090 Vienna,
Austria
PHARMACOLOGICAL RESCUE OF DOPAMINE TRANSPORTER MUTANTS LINKED WITH INFANTILE PARKINSONISM-DYSTONIA
Combinatorial Chemistry (Track)
SESSION SPEAKER
Ying Wang
Principal Research Scientist, Head-High Throughput Chemistry Group,
USA
CHEMISTRY IN THE FAST LANE-ENABLING TECHNOLOGIES FOR DRUG DISCOVERY
Diabetes and Obesity Drug Discovery and Therapy (Track)
SESSION SPEAKER
Tarek M. Mahfouz
Department of Pharmaceutical and Biomedical Sciences Raabe, College of Pharmacy, Ohio Northern University Ada, Ohio,
USA
SMALL MOLECULE AFFINITIES FOR SIRT-1 DEACETYLASE ENZYME
Drug Delivery & Targeting (Track)
TRACK CHAIRS
Monika Schäfer-Korting
Freie Universität Berlin, Berlin,
Germany
RETHINKING DRUG DEVELOPMENT – IMPROVING TRANSLATIONAL RESEARCH
Reinhard Neubert
Institute of Pharmacy Martin Luther University Halle-Wittenberg Wolfgang-Langenbeck-Str. 4
Germany
Title Awaited
Sophia Antimisiaris
Laboratory of Pharmaceutical Technology Department of Pharmacy University of Patras
Greece
Title Awaited
SESSION SPEAKER
A. Sharma
Chemistry & Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859,
USA
DRUG ENTRAPMENT IN DENDRIMERS
Christian Zoschke
Institute of Pharmacy (Pharmacology and Toxicology), Freie Universität Berlin, Königin-Luise-Str. 14, 14195 Berlin,
Germany
THE BARRIER FUNCTION OF ORGANOTYPIC NON-MELANOMA SKIN CANCER MODELS
Burkhard Kleuser
Department of Toxicology, University of Potsdam, Potsdam,
Germany
CROSSTALK BETWEEN CORE-MULTISHELL NANOCARRIERS AND ANTIGEN-PRESENTING CELLS OF THE SKIN
Eckart Ruehl
Physical Chemistry, Institute for Chemistry and Biochemistry, Freie Universitaet Berlin, Berlin,
Germany
TOPICAL DRUG DELIVERY INTO SKIN PROBED BY LABEL-FREE SPECTROMICROSCOPY
Daniel Kandelman
Faculty of Dental Medicine, University of Montreal, Montreal,
Canada
A NEW TOOL FOR ANTISEPTIC IRRIGATION AND CLEANING PERIODONTAL POCKETS; ITS IMPACT IN ORAL AND GENERAL HEALTH
Ulrike Alexiev
Department of Physics, Freie Universität Berlin, Berlin,
Germany
ADVANCED TIME-RESOLVED FLUORESCENCE MICROSCOPY FOR INVESTIGATING NANOCARRIER AND DRUG DELIVERY
Muhammad Qadir
Institute of Chemistry, University of the Punjab, Punjab,
Pakistan
NOVEL RADIOLABELED POLYDENTATE LIGANDS AS POTENTIAL DIAGNOSTIC PROBES
POSTER PRESENTER
Yoshio Hamada
Faculty of Frontiers of Innovative Research in Science and Technology, Konan University, Hyogo,
Japan
NOVEL HIV-1 PROTEASE INHIBITOR PRODRUGS
Yoshio Hamada
Faculty of Frontiers of Innovative Research in Science and Technology, Konan University, Hyogo,
Japan
DESIGN OF BACE1 INHIBITERS POSSESSING A MEDIUM-RING STRUCTURE AT THE P3 POSITION
Genomics (Track)
POSTER PRESENTER
Jennifer Normanly
UMass Amherst BioFoundry, Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst,
USA
MULTIPLEX SG CAP PLATFORM-BASED DRUG LEAD DISCOVERY USING FOCUSED PLANT CELL CULTURE LIBRARY: EFFICIENT SCREENING TECHNOLOGY FOR INHIBITORS OF PROTEIN-PROTEIN INTERACTIONS USING SOL-GEL ENTRAPMENT OF PLANT CELL CULTURE EXTRACTS
Genomics (Track)
TRACK CHAIR
Vito M. Fazio
Laboratory of Oncology, San Giovanni Rotondo (FG),
Italy
Title Awaited
INVITED SPEAKER
Henry M. Sobell
Department of Radiation Biology and Biophysics, University of Rochester, Rochester,
USA
THE CENTERS OF PREMELTONS SIGNAL THE BEGINNING AND ENDS OF GENES
TRACK SECRETARY
Van Steen Kristel
GIGA-R, Medical Genomics Université de Liège
Germany
SYSTEMS GENETICS FOR PRECISION MEDICINE
SESSION SPEAKER
Doris Vandeputte
KU Leuven – University of Leuven, Department of Microbiology and Immunology, Rega Institute, Herestraat 49, B-3000 Leuven, Belgium; VIB, Center for Microbiology, Kasteelpark Arenberg 31, B-3000 Leuven, Belgium; Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels,
Belgium
THE GUT MICROBIOME IN HEALTH AND DISEASE, THE IMPORTANCE OF QUANTITATIVE MICROBIOME PROFILING
Fentaw Abegaz
GIGA-R Medical Genomics – BIO3, University of Liège, Liège, Belgium and WELBIO, University of Liège, Liège,
Belgium
EPISTASIS DETECTION FOR HUMAN COMPLEX DISEASES IN STRUCTURED POPULATIONS
POSTER PRESENTER
Van Steen K.
GIGA-R Medical Genomics - BIO3, University of Liege, Liege,
Belgium
DETERMINING FINE POPULATION STRUCTURE USING ITERATIVE PRUNING
High-throughput Screening & Laboratory Automation (Track)
SESSION SPEAKER
Ravindra Peravali
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen,
Germany
DRUG DISCOVERY AND TESTING USING HIGH-THROUGHPUT MORPHOLOGICAL AND BEHAVIORAL SCREENING OF ZEBRAFISH LARVAE
POSTER PRESENTER
F. Ghanbari
Division of Plastic Surgery, Department of Surgery, McGill University, Montreal Quebec,
Canada
STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF A NOVEL ENDOGENOUS STEROID, ESTRADIENOLONE-LIKE STRUCTURE (ED), IN HUMAN PREGNANCY URINE
Hot Topics in Medicinal Chemistry (Track)
TRACK CHAIRS
Pierfausto Seneci
Chemistry Dept., University of Milan,
Italy
FUNCTION-ORIENTED SYNTHESIS (FOS), RATIONAL DESIGN AND SERENDIPITY: THE AZA-TANSHINONE STORY
Hidayat Hussain
Center for Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA, 92093-0204, USA and UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O Box 33, Postal Code 616, Nizwa,
Sultanate of Oman
NEW STRATEGIES TO GENERATE NEW CHEMICAL DIVERSITY FOR DRUG DISCOVERY
SESSION SPEAKER
Andrea Cavalli
University of Bologna and Italian Istitute of Tecnology, Italy
Italy
SYNTHETIC LETHALITY TRIGGERED BY COMBINING OLAPARIB WITH BRCA2-RAD51 DISRUPTORS
Daniele Passarella
Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano,
Italy
SELF-ASSEMBLING DRUG-CONJUGATES FOR ANTI-CANCER TARGETING AND TREATMENT
Christine Gravier-Pelletier
Université Paris Descartes, Sorbonne Paris Cité, CICB-Paris, UMR CNRS 8601, LCBPT 45 Rue Des Saints Pères, 75270 Paris 06,
France
BACTERIAL PEPTIDOGLYCAN, STILL A SOURCE OF INSPIRATION TOWARDS ANTIBIOTICS
Toshiaki Matsubara
Department of Chemistry, Faculty of Science, Kanagawa University, 2946, Tsuchiya, Hiratsuka, Kanagawa 259-1293,
Japan
AN INSIGHT INTO THE MECHANISM OF THE ELECTRON-TRANSFER INDUCED REPAIR OF THE (6-4) T-T PHOTOPRODUCT OF DNA BY THE PHOTOLYASE. A COMPUTATIONAL STUDY
Steven Harper
IRBM-Science Park, Via Pontina km 30,600, Pomezia, 00071 Rome,
Italy
SELECTIVE HDACI’S FOR NON-ONCOLOGICAL APPLICATIONS
Aramini Andrea
Discovery Department, R&D Dompé SpA, L’Aquila,
Italy
TRPM8 BLOCKERS: RATIONAL DESIGN OF NOVEL POTENT AND SELECTIVE SMALL MOLECULE CHEMICAL SERIES FOR NEUROPATHIC PAIN RELIEF
Brijesh Rathi
Department of Chemistry, Massachusetts Institute of Technology, Massachusetts Avenue, Cambridge MA 02139,
USA
DISCOVERY OF MULTISTAGE ANTIMALARIALS: SYNERGISTIC FUSION OF PRIVILEGED BIOACTIVE SCAFFOLDS TRIGGERS GROWTH INHIBITION OF MALARIA PARASITE PLASMODIUM FALCIPARUM
POSTER PRESENTERS
Ekeanyanwu Raphael Chukwuma
Department of Biochemistry, Faculty of Medicine, Imo State University Owerri, Imo State,
Nigeria
FLAVONOID-RICH FRACTION OF THE MONODORA TENUIFOLIA SEED EXTRACT ATTENUATES BEHAVIOURAL ALTERATIONS AND OXIDATIVE DAMAGE IN FORCED-SWIM STRESSED RATS
Gaia Fumagallia
Department of Chemistry, University of Milan, Milano,
Italy
SELF-ASSEMBLED 4-(1,2-DIPHENYLBUT-1-EN-1-YL) ANILINE BASED NANOPARTICLES
Hot Topics in Natural Products (Track)
SESSION SPEAKER
Geng-Long Hsu
Microsurgical Potency Reconstruction and Research Center, 3F 88, Wen-Hu Street Nei-Hu District 114, Taipei,
Taiwan
DISCOVERY OF A NATURAL PRODUCT FOR THE TREATMENT OF ERECTILE DYSFUNCTION
Fatema Habeeb
Medical Laboratory Sciences, Kuwait University,
Kuwait
A MIXTURE OF CAMEL MILK AND URINE SHOWS ANTICANCER PROPERTIES IN VITRO AND IN VIVO: AN EVIDENCE OF A TRADITIONAL ETHNOMEDICINE PRACTICE
Geng-Long Hsu
Microsurgical Potency Reconstruction and Research Center, 3F 88, Wen-Hu Street Nei-Hu District 114, Taipei,
Taiwan
A COMPOUND INHIBITS JOINTLY PHOSPHODIESTERASE 1 AND 5
POSTER PRESENTER
MinKyun Na
Pharmacy Department, Chungnam National University, Daejeon,
South Korea
SMALL MOLECULE ANTICOAGULANTS DERIVED FROM SCOLOPENDRA SUBSPINIPES MUTILANS
Inflammation & Immunology (Track)
TRACK CHAIRS
Stephen Thomas Sonis
Brigham and Women's Hospital, Boston, Massachusetts,
USA
OPPORTUNITIES FOR TARGET IDENTIFICATION TO PREVENT AND TREAT CANCER REGIMEN-RELATED TOXICITIES
Bagrat A. Shainyan
Head of Laboratory Irkutsk Institute of Chemistry Siberian Division of Russ. Ac. Sci.
Russia
Title Awaited
SESSION SPEAKER
Dominic Richard Beal
Biomodels, LLC, 313 Pleasant Street, Watertown, MA 02472,
USA
MURINE MODELS OF GVHD - MODIFICATIONS AND ENHANCEMENTS TO IMPROVE RELIABILITY AND TRANSLATABILITY
Oreola Donini
Research & Development, Soligenix, Inc., New Jersey,
USA
MODULATION OF INNATE IMMUNITY IN THE TREATMENT OF INFLAMMATION-DRIVEN AND INFECTION-DRIVEN DISEASE
Gregory Zugates
Alivio Therapeutics, Inc., 501 Boylston St. Suite 6102, Boston, MA 02116,
USA
AN INFLAMMATION-TARGETED HYDROGEL DRUG DELIVERY PLATFORM: APPLICATION TO INTERSTITIAL CYSTITIS
B.J. Bormann
Supportive Therapeutics, LLC, Cambridge, MA,
USA
RADIATION-INDUCED TISSUE DAMAGE IS ATTENUATED BY AN NRF2 INDUCER
Michael Bonkowski
The Paul F. Glenn Labs, Harvard Medical School, Boston, MA 02115,
USA
PROTECTION FROM RADIATION BY SMALL MOLECULES THAT RAISE NAD
Arthur P. Bertolino
Innovation Pharmaceuticals, Beverly, Massachusetts,
USA
BRILACIDIN, A NOVEL ANTI-INFLAMMATORY DRUG CANDIDATE: SHOWS POTENTIAL BENEFIT IN BOTH SEVERE ORAL MUCOSITIS AND IN INFLAMMATORY BOWEL DISEASE
Robert A. Beardsley
Research & Development Department, Galera Therapeutics, Inc,
USA
PENTAAZA MACROCYCLES REDUCING TOXICITY AND INCREASING EFFICACY OF RADIATION THERAPY
POSTER PRESENTER
Joanna Wojtkiewicz
Department of Pathophysiology, Faculty of Medical Sciences, University of Warmia, Olsztyn,
Poland
CYTOKINE AND CHEMOKINE PROFILES IN ALS PATIENTS UNDERGOING STEM CELL EXPERIMENTAL TREATMENT
In-silico Drug Design and In-silico Screening (Track)
SESSION SPEAKER
R.S. Rathore
Centre for Biological Sciences (Bioinformatics), School of Earth, Biological and Environmental Sciences, Central University of South Bihar, Patna 800 014,
India
NOVEL DUAL-BINDING CATION-Π INHIBITORS OF ACHE: DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION
Innovative Drug Discovery and Nanotechnology (Track)
TRACK CHAIRS
Antonino Mazzaglia
Consiglio Nazionale delle Ricerche-Istituto per lo Studio dei Materiali Nanostrutturati (CNR-ISMN) c/o Dept ChiBioFarAm, University of Messina, Messina,
Italy
NANOMATERIALS BASED ON CYCLODEXTRIN: DESIGN, ADVANCES IN (PHOTO) THERAPEUTICS DELIVERY AND BIO-PERFORMANCES
SESSION SPEAKER
José García Suárez
Center for Genetic Engineering and Biotechnology, Havana,
Cuba
PRODUCTION OF A NOVEL RECOMBINANT POLYPEPTIDE FROM SERRATIA MARCESCENS FOR CANCER THERAPY
Lajos Szente
CycloLab Cyclodexrin Research and Development Laboratory Ltd., Illatos út 7. 1097 Budapest,
Hungary
THERAPEUTIC AND DIAGNOSTIC UTILITY OF CYCLODEXTRIN DERIVATIVES
Hidetoshi Arima
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973,
Japan
POTENTIAL USE OF CYCLODEXTRIN DERIVATIVES AS THERAPEUTIC AGENTS FOR LYSOSOMAL STORAGE DISORDERS
Géraldine Gouhier
University of Rouen, UMR CNRS 6014 COBRA,
France
CYCLODEXTRINS: AN APPROPRIATE SCAFFOLD FOR NEW MRI THERANOSTIC PROBES
Valentina Rapozzi
Department of Medical and Biological Sciences, University of Udine, P.le Kolbe 4, 33100 Udine,
Italy
INNOVATIVE DRUGS IN PHOTODYNAMIC THERAPY
Keiichi Motoyama
Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Science, Kumamoto University, Kurokami Chuo-ku Kumamoto,
Japan
MITOPHAGY-MEDIATED NOVEL CELL DEATH INDUCED BY FOLATE-APPENDED METHYL-β-CYCLODEXTRIN
Mostafa Mostafa Abo Elsoud
Microbial Biotechnology, National Research Centre, Cairo,
Egypt
EFFECT OF GAMMA IRRADIATION ON BIOGENIC PRODUCTION OF TELLURIUM NANOPARTICLES
POSTER PRESENTER
S.J. Owonubi
Biological Sciences, North-West University, Mmabatho,
South Africa
BIOAVAILABILITY IMPROVEMENT OF ACARBOSE BY ACRYLATION TO POLYETHYLENE GLYCOL HYDROGELS
Nicole J. Bassous
Chemical Engineering, Northeastern University, Boston, MA 02115,
USA
PEPTIDE-ENRICHED NANOCARRIERS FOR THE GROWTH INHIBITION OF ANTIBIOTIC-RESISTANT BACTERIA
Proteomics & Bioinformatics (Track)
TRACK CHAIR
Fazlul Huq
School of Medical Sciences, Sydney Medical School, University of Sydney,
Australia
TUMOUR ACTIVE PHYTOCHEMICALS FOUND TO ENHANCE PLATINUM ACTION IN OVARIAN TUMOUR MODELS
Protein & Peptide Sciences (Track)
TRACK CHAIRS
E. Brad Thompson
Center for Nuclear Receptors and Cell Signaling, Dept. of Biology and Biochemistry, University of Houston, TX 77204; Center for Structural Biology and Molecular Biophysics, Dept. of Biochemistry and Molecular Biology, Univ. of Texas Medical Branch, Galveston, TX 77551,
USA
PROTEIN INTRINSIC DISORDER IN DRUG DESIGN AND USE
SESSION SPEAKER
Collin Stultz
Professor of Electrical Engineering and Computer Science, Institute for Medical Engineering and Science, Massachusetts Institute of Technology,
USA
DYNAMICS OF ALPHA-SYNUCLEIN AGGREGATION
Raj Kumar
Department of Basic Sciences; Geisinger Commonwealth School of Medicine; Scranton, PA-18509
USA
ROLE OF SITE-SPECIFIC PHOSPHORYLATION IN THE ACTION OF GLUCOCORTICOID RECEPTOR
William A. Elam
Department of Basic Sciences; Geisinger Commonwealth School of Medicine; Scranton, PA-18509
USA
A PROTEIN STABILIZING OSMOLYTE RESTORES MUTANT GLUCOCORTICOID RECEPTOR BINDING
Iain J. McEwan
Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland,
UK
THE INTRINSICALLY DISORDERED AMINO TERMINAL DOMAIN OF STEROID HORMONE RECEPTORS AS A NOVEL DRUG TARGET: IDENTIFICATION OF SMALL MOLECULE INHIBITORS
Jing Li
Program in Cellular and Molecular Medicine, Boston Children’s Hospital and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA
USA
INTRINSIC DISORDER AND ALLOSTERY IN GLUCOCORTICOID RECEPTOR
Lidija Covic
Center for Hemostasis and Thrombosis Research, Molecular Oncology Research Institute; Tufts Medical Center; Boston, MA
USA
PEPDUCINS AS ALLOSTERIC AGENTS AND THERAPEUTICS TO PREVENT CORONARY ARTERY THROMBOSIS AND NASH
Lei Li
School of Pharmacy, Queen's University, Belfast,
UK
DISCOVERY AND PHARMACOLOGICAL EVALUATION OF NOVEL CAERIDINS WITH SMOOTH MUSCLE ACTIVITIES, ISOLATED FROM THE SKIN SECRETION OF THE AUSTRALIAN WHITE’S TREE FROG, LITORIA CAERULEA
POSTER PRESENTER
Leiter, E.
Department of Biotechnology and Microbiology, University of Debrecen, Debrecen, Hungary
THE PENICILLIUM CHRYSOGENUM ANTIFUNGAL PROTEIN (PAF) CAN BE A PROMISING ANTIMYCOTIC CANDIDATE
Yuxin Wu
Department of Pharmacy, Queen's University Belfast, Belfast, United Kingdom
A NOVEL DERMASEPTIN PEPTIDE EXHIBITS ANTICANCER ACTIVITY VIA INDUCTION OF APOPTOSIS AND AUTOPHAGY
Lei Wang
Department of Pharmacy, Queen's University Belfast, Belfast, United Kingdom
A NOVEL PEPTIDE, QUB1999, IDENTIFIED IN PHYLLOMEDUSA BURMEISTERI SKIN
Pharmaceutical Biotechnology (Track)
POSTER PRESENTER
Gulua L.
Department of Food Technology, Agricultural University of Georgia, Tbililsi,
Georgia
BIOLOGICAL ACTIVITY OF GREEN TEA EXTRACT
Kavitha Chandagirikoppal Vijendra
Department of Collegiate Education, Government College for Women Mandya, University of Mysore, Karnataka,
India
CXL146 - A NOVEL CHROMENE DERIVATIVE INDUCES APOPTOSIS THROUGH ER STRESS FOLLOWED BY THE INHIBITION OF NOTCH1 SIGNALING IN MULTIDRUG RESISTANT AML CELLS
Pharmaceutical Research & Development (Track)
TRACK CHAIR
Rathnam Chaguturu
iDDPartners, Princeton Junction, NJ 08550,
USA
DRUG DISCOVERY EFFORTS MIRROR THE PROVERBIAL HYPER CYCLE: WHAT’S NEXT?
POSTER PRESENTER
António J. Ribeiro
Department of Development and Drug Technologies, University of Coimbra, Coimbra,
Portugal
DEVELOPMENT OF A WASHLESS APPROACH FOR LAYER-BY-LAYER ASSEMBLY UPON RESVERATROL NANOCORES
Recent Advances in Spectroscopy (Track)
TRACK CHAIR
Recent Advances in Patient Treatment and Care (Track)
SESSION SPEAKERS
William J. Rowe
Medical University of Ohio at Toledo, Keswick, VA 22947,
USA
NEIL ARMSTRONG SYNDROME AND THERMOREGULATION
Ali Noroozi Mobarake
Management Department, Payame Noor University, Tehran,
Iran
QUALITY OF HEALTH TOURISM IN PATIENTS ADMITTED TO SHIRAZ LEVEL I TRAUMA CENTER A FIELD STUDY OF IRAN
Drug Discovery in Preclinical Research (Track)
TRACK CHAIR
Istvan Nagy
Imperial College London, London,
UK
INTEGRATED APPROACH TO IDENTIFY NEW TARGETS FOR ANALGESICS FOR BURN INJURY-ASSOCIATED PAIN
SESSION SPEAKERS
Maayan Gal
Department of Biochemistry, Migal research center, Kiryat Shmona 11016,
Israel
COMPUTATIONAL AND BIOPHYSICAL TOOLS TOWARDS PPIS DRUG DISCOVERY
Tatsuya Takimoto
Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan; Graduate School of Human and Environmental Studies, Kyoto University, Kobe,
Japan
STUDY ON THE CORRELATION BETWEEN STRUCTURES OF BITHIAZOLE DERIVATIVES AND PLASMID DNA CLEAVAGE ACTIVITY BY USING SIMULATION AND EXPERIMENT
Peter Juhasz
Biogen, Cambridge, MA,
USA
TARGET DISCOVERY FROM PHENOTYPIC SCREENS AND KNOWN COMPOUNDS OF UNKNOWN TARGET
Graham Dempsey
Q-State Biosciences, Harvard University, Cambridge, MA,
USA
ALL-OPTICAL ELECTROPHYSIOLOGY FOR NEUROSCIENCE AND CARDIOVASCULAR DRUG DISCOVERY
Sini Junttila
BIOCOMP, Bioinformatics & Scientific Computing, VBCF - Vienna Biocenter Core Facilities GmbH,
Austria
BIOINFORMATIC NEXT GENERATION SEQUENCING DATA ANALYSIS WORKFLOW FOR PRECLINICAL STUDIES
Paul B. Watkins
Eshelman School of Pharmacy, University of North Carolina, Chapel Hill,
USA
USING QUANTITATIVE SYSTEMS TOXICOLOGY (QST) TO ASSESS DRUG SAFETY: THE EXPERIENCE OF THE DILISIM INITIATIVE
Laszlo Urban
Preclinical Secondary Pharmacology, Novartis Institute for Biomedical Research, Cambridge, MA,
USA
TRANSLATIONAL ASPECTS OF SECONDARY PHARMACOLOGY
Juan Jesus Perez
Department of Chemical Engineering, Universitat Politecnica de Catalunya, BarcelonaTech,
Spain
IDENTIFICATION OF A NOVEL INHIBITORY ALLOSTERIC SITE OF p38 MAP KINASE
Reggie Y. Dela Cruz
Dept of Biology, Central Mindanao University, Bukidnon,
Philippines
ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTICANCER POTENTIALS OF PHILIPPINE FERNS AND LYCOPODS
POSTER PRESENTER
Sylvie Cosnier-Pucheu
Department of Research, Cilcare, Montpellier,
France
AMPLITUDE OF THE RESPONSE OF THE EVOKED POTENTIAL OF THE INFERIOR COLLICULUS AS A MARKER
Edmond J. Feris
Molecular Systems Biology, Geisel School of Medicine at Dartmouth College, Lebanon,
USA
TRRAPING MYC: AIMING AT A MOVING TARGET
Liza Ngo
Pharmaceutical Biomedical Science, University of Georgia, Athens,
USA
THE DESIGN AND UTILIZATION OF THE SCINTILLATION PROXIMITY ASSAY TO SCREEN FOR P300 INHIBITORS
Michelle Hung
St. Mark's School, Southborough, Massachusetts, MA,
USA
PTX-NPS ENCAPSULATED BY METAL-POLYPHENOL: SYNTHESIS AND CYTOTOXICITY
Medical Imaging (Track)
SESSION SPEAKERS
Yi Zhang
Massachusetts General Hospital, Harvard Medical School, Boston, MA,
USA
IN VIVO IMAGING OF NEUXIAL INFLAMMATION IN SCIATICA PAIN WITH PET/MRI
POSTER PRESENTER
Jashim Uddin
Biochemistry Department, Vanderbilt University, Nashville, TN 37235,
USA
CXL146 - A NOVEL CHROMENE DERIVATIVE INDUCES APOPTOSIS THROUGH ER STRESS FOLLOWED BY THE INHIBITION OF NOTCH1 SIGNALING IN MULTIDRUG RESISTANT AML CELLS
Molecular Diagnostics (Track)
POSTER PRESENTER
N. Gumanova
Department of Biochemistry, National Research Center for Preventive Medicine, Moscow,
Russia
SERUM NITRITE AND NITRATE LEVELS, NOX, IN CARDIOVASCULAR MORTALITY STUDY: 3 AND 7 YEAR FOLLOW UP
Nutraceutical Drug Discovery & Therapy (Track)
SESSION SPEAKERS
Chandrakanth Emani
Western Kentucky University-Owensboro, Kentucky,
USA
BASIL, GINGER, NEEM AND TOBACCO EXTRACTS AS ALTERNATIVE AND INTEGRATIVE TREATMENT OPTIONS FOR CANCER
Waseem Hassan
University of Peshawar, Peshawar -25120, Khyber Pakhtunkhwa,
Pakistan
EFFECT OF CO-60 GAMMA RADIATION ON PHYSICOCHEMICAL PROPERTIES OF STORED PEACH (PRUNUS PERSICA)
Regenerative Medicine (Track)
SESSION SPEAKERS
Nassim H. Abi Chahine
The Lebanese-Canadian Hospital, Beirut,
Lebanon
THE REGENTIME* PROCEDURE, A SAFE WAY FOR REGENERATION
POSTER PRESENTER
T.W. Chiou
Department of Life Science, Graduate Institute of Biotechnology, Hualien,
Taiwan
ADIPOSE-DERIVED STEM CELLS FACILITATE THE RECOVERY OF PANCREATIC FUNCTION AND ABROGATE NICOTINAMIDE
Structural Biology (Track)
SESSION SPEAKER
B. Padmanabhan
Department of Biophysics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore – 560029,
India
STRUCTURE-BASED DRUG DISCOVERY OF SMALL MOLECULE MODULATORS FOR HUMAN SUPEROXIDE DISMUTASE I (HSOD1) ASSOCIATED WITH ALS
POSTER PRESENTER
Eloise Mastrangelo
Biophysics Institute, National Research Council, Milano,
Italy
TYPE I BIR DOMAIN INHIBITORS IN CANCER THERAPY: SEARCHING DRUGS FOR REGULATION OF THE NF-B PATHWAY
Diaz-Saez L
Nuffield Department of Medicine, Structural Genomics Consortium, University of Oxford, Oxford,
United Kingdom
TYPE I BIR DOMAIN INHIBITORS IN CANCER THERAPY: SEARCHING DRUGS FOR REGULATION OF THE NF-B PATHWAY
Traditional Chinese Medicine (Track)
POSTER PRESENTER
Gheda Alsaif
Department of Biology, Middle Tennessee State University, Murfreesboro,
USA
EVALUATION OF FOURTEEN AURONE DERIVATIVES AS POTENTIAL ANTI-CANCER AGENTS
Translational Medicine (Track)
SESSION SPEAKER
Roman Maciej Kalina
The Russell H. Morgan Department of Radiology and Radiological Science, School of Medicine Johns Hopkins University Baltimore, MD 21287,
United States
PLACEBO EFFECT AS STARTING POINT OF THE USE OF INNOVATIVE AGONOLOGY IN THE THERAPY AND TREATMENT

ABSTRACTS IN PROCESS

SESSION SPEAKER
Michael Rossbach
Biotech Développement Conseils, 182 Avenue Charles de Gaulle, 92200 Neuilly-sur-Seine, Paris,
France
ncRNAs ARE KEY REGULATORS IN TUMORIGENESIS – WHAT’S REGULATED IN ‘GENE REGULATION’?
Jaspreet Kaur Randhawa
School of Engineering, Indain Institute of Technology, Mandi (IITMandi)
India
SINGLE STEP SYNTHESIS OF CURCUMIN LOADED ZEOLITIC IMIDAZOLATE FRAMEWORKS: PH STIMULI RELEASE FOR C
Ramesh Chandra
Dr. B.R Ambedkar Center for Biomedical Research, University of Delhi, Delhi - 110007,
India
A JOURNEY FROM BENCH TO BED NOSCAPINE: OPIUM ALKALOID. A POTENTIAL CHEMOTHERAPEUTIC AGENT
Doni Dermawan
Dept. of Pharmacy, Universitas Padjadjaran, Jawa Barat 45363,
Indonesia
IN SILICO AND TOXICITY STUDY OF THE COMBINATION OF ROSELLE (HIBISCUS SABDARIFFA L.) AND GARLIC (ALLIUM SATIVUM L.)
Peter I. Ejidike
Department of Chemistry, Faculty of Applied and Computer Sciences, Vaal University of Technology, Vanderbijlpark 1911,
South Africa
CU(II) COMPLEXES OF TRIDENTATE SCHIFF BASE LIGAND: SYNTHESIS, CHARACTERI-ZATION AND BIOLOGICAL EVALUATION
Maurizio Botta
Dipartimento Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena, Via A. Moro 2, I-53100 Siena,
Italy
THE FIRST MOLECULE INTERACTING WITH A HOST PROTEIN FOR THE INHIBITION OF MULTIPLE VIRUSES
Mohammad Yasin Mohammad
Department of Pharmacy, Faculty of Pharmacy, Middle East University, Amman-11831,
Jordan
NEW MONOTERPENOID BY BIOTRANSFORMATION OF THYMOQUINONE USING ASPERGILLUS NIGER
Nitin Mahendra Chauhan
College of Natural and Computational Sceinces, Dilla University, Dilla 419,
Ethiopia
FUNGAL BIOFILMS: CHALLENGES AND STRATEGIC APPROACH TO OVERCOME THE GAINSAY IN BIOMEDICAL SCIENCE
Adam Zweifach
Dept of Molecular and Cell Biology, University of Connecticut, Connecticut, Storrs,
United States
A NOVEL ENSEMBLE APPROACH TO PROVIDING SMALL MOLECULE SUPPORT FOR VALIDATION OF CELLULAR TARGETS CON